EEG Individual Alpha Frequencies May Predict Clinical Outcome in TMS Treatment

Background: Recent research has explored a possible relationship between patients’ individual alpha frequency (IAF) and their response to Transcranial Magnetic Stimulation (TMS) treatment. The purpose of this study was investigate correlation IAF change in the quality life (QoL) patients with major depressive disorder (MDD). Methods: Retrospective chart review performed on 55 depression from an outpatient psychiatric clinic. Subjects were aged 18-71 who completed full course at least 30 TMS treatments initially received 10 Hz treatment left dorsolateral prefrontal cortex (L-DLPFC). Baseline determined initial resting-state, 5 minutes eyes-closed dry wireless EEG (Cognionics, San Diego). Patient QoL measured before first last treatment, using question 18 Clinically Useful Depression Outcome Scale (CUDOS-18). Results: Four had two equal peaks baseline EEG. Eleven no clearly identifiable excluded. For subjects 8, 9, 10, 11, or 12 Hz, % reported increase 44%, 79%, 40%, 75%, 0%, respectively. mean across all groups 12.8%. Conclusions: Patients experienced improved after most significant improvement 9 Hz. Personalizing by measuring may improve outcome terms life. Further studies are needed. Conflicts interest: None Funding: Disclosures: